Role of green tea catechins in modulating stromal-epithelial interaction in prostate cells

Recent years have witnessed a significant interest in phytonutrients as treatment module for range of diseases, including cancers. Catechins, predominant green tea are potent antioxidants belonging to the flavonoid family that been linked epidemiologically lower prevalence prostate pathologies Asian nations. In present work, we investigated ameliorative potential catechins (epigallocatechin, EGC, and epigallocatechin 3-gallate, EGCG) on aberrant proliferation normal epithelial cells driven by paracrine action stromal medium, conditioned with estradiol (E2) dihydrotestosterone (DHT) (20 pM 10 nM respectively). It was observed EGC (5 µM) significantly inhibited induced medium (CM), decreased expression ERα, ERβ, AR, CK05, CK18, PSA. Further, CM collected after pre-treatment EGCG (0.75 µM), had an inhibitory effect cell proliferation, reduction CK05 while PSA were increased. These findings suggest helps downregulating is able downregulate proliferative secretome. insights will help deciphering preventive measures against involving stromal-epithelial cross-talk.